![]() Centers for Disease Control and Prevention. Focal epilepsy: Causes and clinical features. In: Harrison's Principles of Internal Medicine. National Institute of Neurological Disorders and Stroke. The loss of brain cells in the hippocampus may cause memory problems. This area of the brain is called the hippocampus. Over time, repeated temporal lobe seizures can cause the part of the brain that's responsible for learning and memory to shrink. A temporal lobe seizure is a focal seizure that originates in one of the temporal lobes. If this happens in just one area of the brain, the result is a focal seizure. If there's a burst of electrical activity in many brain cells, a seizure may occur.
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